11 Sep '13, 3pm

European College of Sport Science Review

Bouchard's definition of an adverse response as more than two standard deviations of technical error in the marker is misleading, if not wrong; what matters is a clinically important change, not a clear measurable change. If the clinically important change is larger than the measurable change, the proportion of adverse responders will be lower than Bouchard and colleagues have estimated. He also did not mention that a difference in a marker that predicts a clinically important difference in disease outcome in population studies (the only way at present to estimate a clinically important difference in a marker) is not necessarily the same as a clinically important change in a training study. In short, exercise might still be good for the individual whose markers change apparently for the worse. It would be ethically and logistically impossible to address this problem with a...

Full article: http://sportsci.org/2013/ECSS.htm

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